Jingsong Yuan

Profile Headshot

Overview

Academic Appointments

  • Assistant Professor of Radiation Oncology (in the Center for Radiological Research) at CUMC

Credentials & Experience

Education & Training

  • MD, 2001 Clinical Medicine, Tongji Medical University (China)
  • PhD, 2006 Oncology, Chinese Academy of Medical Sciences (China)

Honors & Awards

  • 2015 The NCI Transition Career Development Award (K22)
  • 2014 Susan G. Komen CCR Award
  • 2006 Young Investigator award, the National Cancer Forum for Young Scientists, Hunan, China
  • 2002 - 2005 Excellent Graduate Awards, CAMS&PUMC
  • 2001 Excellent Graduate Awards, Tongji Medical University
  • 2000 United Laboratories Golden Scholarship, Tongji Medical University
  • 1997 - 2001 Excellent Student Awards, Tongji Medical University

Research

DNA damage response and DNA repair, specifically DNA replication stress response and homologous recombination (HR) repair; Tandem affinity purification (TAP) for studying protein-protein interactions; CRISPR/cas9 mediated genome editing in mammalian cells including gene knock-out, knock-in, genomic deletion and translocation.

My goal is to leverage my expertise in the field of DNA damage repair for translation into the realm of cancer biology and therapeutics. My main interest is to elucidate the underlying molecular mechanisms that result in genomic instability and tumorigenesis.

Grants

BMI1 RESISTANCE PATHWAY AND IMMUNE CHECKPOINT BLOCKADE IN LUNG CANCER (Private)

Jul 1 2019 - Jun 30 2020

A NOVEL PROTEIN COMPLEX CONTROLS HOMOLOGOUS RECOMBINATION REPAIR IN BREAST CANCER (Federal Gov)

Sep 30 2015 - Aug 31 2019

A NOVEL PROTEIN COMPLEX CONTROLS HOMOLOGOUS RECOMBINATION REPAIR IN BREAST CANCER (Federal Gov)

Sep 30 2015 - Aug 31 2018

A NOVEL PROTEIN COMPLEX CONTROLS HOMOLOGOUS RECOMBINATION REPAIR IN BREAST CANCER (Federal Gov)

Sep 30 2015 - Aug 31 2018

EXPLOITING THE VULNERABILITIES OF BREAST CANCER WITH HOMOLOGOUS RECOMBINATION DEFICIENCY (Private)

Feb 9 2017 - Sep 26 2017

Selected Publications

  • Jiang M, Li H, Zhang Y, Yang Y, Lu R, Liu K, Lin S, Lan X, Wang H, Wu H, Zhu J, Zhou Z, Xu J, Lee DK, Zhang L, Lee YC, Yuan J, Abrams JA, Wang TC, Sepulveda AR, Wu Q, Chen H, Sun X, She J, Chen X, Que J. Transitional basal cells at the squamous-columnar junction generate Barrett's oesophagus. Nature. 2017 Oct 26;550(7677):529-533.
  • Li X, Gao M, Choi JM, Kim BJ, Zhou MT, Chen Z, Jain AN, Jung SY, Yuan J, Wang W, Wang Y, Chen J. Clustered, Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-coupled Affinity Purification/Mass Spectrometry Analysis Revealed a Novel Role of Neurofibromin in mTOR Signaling. Mol Cell Proteomics. 2017 Apr;16(4):594-607.
  • Lee YC, Zhou Q, Chen J, Yuan J. RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response. Curr Biol. 2016 Dec 19;26(24):3257-3268.
  • Liu L, Huang J, Wang K, Li L, Li Y, Yuan J, Wei S. Identification of hallmarks of lung adenocarcinoma prognosis using whole genome sequencing. Oncotarget. 2015 Nov 10;6(35):38016-28.
  • Xu G, Chapman JR, Brandsma I, Yuan J, Mistrik M, Bouwman P, Bartkova J, Gogola E, Warmerdam D, Barazas M, Jaspers JE, Watanabe K, Pieterse M, Kersbergen A, Sol W, Celie PH, Schouten PC, van den Broek B, Salman A, Nieuwland M, de Rink I, de Ronde J, Jalink K, Boulton SJ, Chen J, van Gent DC, Bartek J, Jonkers J, Borst P, Rottenberg S. REV7 counteracts DNA double-strand break resection and affects PARP inhibition. Nature. 2015 May 28;521(7553):541-4.
  • Zhang P, Wang L, Debeb B, Zhang J, Yuan J, Wang M, Chen D, Sun Y, Woodward W, Liu Y, Dean D, Ang K, Chen J, Ma L. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol. 2014 Aug 3. doi: 10.1038/ncb3013.