Igor Shuryak, PhD
- Assistant Professor of Radiation Oncology (in the Center for Radiological Research) at CUMC
Credentials & Experience
Education & Training
- BA, 1997 Biology and Environmental Sciences, Columbia College-Columbia University
- MD, 2001 Medicine, SUNY - Downstate Medical Center
- PhD, 2006 Environmental Health Sciences, Columbia University, Mailman School of Public Health
Honors & Awards
- 2011 Radiation Research Editor's Award, Radiation Research Society
- 2014 Radiation Research Jack Fowler Award, Radiation Research Society
My main research focus involves quantitatively modeling radiation effects including radiation carcinogenesis, normal tissue complications, radioresistance and non-targeted effects. My previous training and experience have been interdisciplinary, starting with biology (BA from Columbia University) and medicine (MD from SUNY Downstate College of Medicine). I completed the intensive Cancer Training Program (Columbia University, Mailman School of Public Health), where for three years I improved my skills in cancer epidemiology and biostatistics. I received a PhD degree with distinction in 2010 from the department of Environmental Health Sciences (Columbia University, Mailman School of Public Health) for mechanistic mathematical modeling of radiation-induced carcinogenesis. My work in this field, and also in the field of resistance to ionizing radiation, has resulted in multiple peer-reviewed publications.
- Mechanistic mathematical modeling of radiation-induced carcinogenesis, particularly second cancers induced by radiotherapy in patients treated for primary tumors
- Shuryak I, Sachs RK, Hlatky L, Little MP, Hahnfeldt P, Brenner DJ. Radiation-induced leukemia at doses relevant to radiation therapy: modeling mechanisms and estimating risks. J Natl Cancer Inst. 2006 Dec 20;98(24):1794-806. PubMed PMID: 17179481.
- Shuryak I, Hahnfeldt P, Hlatky L, Sachs RK, Brenner DJ. A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: approach. Radiat Environ Biophys. 2009 Aug;48(3):263-74. PubMed PMID: 19536557; PubMed Central PMCID: PMC2714893.
- Shuryak I, Hahnfeldt P, Hlatky L, Sachs RK, Brenner DJ. A new view of radiation-induced cancer: integrating short- and long-term processes. Part II: second cancer risk estimation. Radiat Environ Biophys. 2009 Aug;48(3):275-86. PubMed PMID: 19499238; PubMed Central PMCID: PMC2714894.
- Shuryak I, Sachs RK, Brenner DJ. Cancer risks after radiation exposure in middle age. J Natl Cancer Inst. 2010 Nov 3;102(21):1628-36. PubMed PMID: 20975037; PubMed Central PMCID: PMC2970575.
- Experimental and theoretical research to identify novel approaches to prevent cancer in humans
- Brenner DJ, Shuryak I, Russo S, Sachs RK. Reducing second breast cancers: a potential role for prophylactic mammary irradiation. J Clin Oncol. 2007 Nov 1;25(31):4868-72. PubMed PMID: 17971581.
- Shuryak I, Smilenov LB, Kleiman NJ, Brenner DJ. Potential reduction of contralateral second breast-cancer risks by prophylactic mammary irradiation: validation in a breast-cancer-prone mouse model. PLoS One. 2013;8(12):e85795. PubMed PMID: 24376895; PubMed Central PMCID: PMC3869887.
- Mathematical modeling of the mechanisms of resistance to ionizing radiation
- Shuryak I. Advantages of Synthetic Noise and Machine Learning for Analyzing Radioecological Data Sets. PLoS One. 2017;12(1):e0170007. PubMed PMID: 28068401; PubMed Central PMCID: PMC5222373.
- Shuryak I, Matrosova VY, Gaidamakova EK, Tkavc R, Grichenko O, Klimenkova P, Volpe RP, Daly MJ. Microbial cells can cooperate to resist high-level chronic ionizing radiation. PLoS One. 2017;12(12):e0189261. PubMed PMID: 29261697; PubMed Central PMCID: PMC5738026.
- Shuryak I, Dadachova E. Quantitative Modeling of Microbial Population Responses to Chronic Irradiation Combined with Other Stressors. PLoS One. 2016;11(1):e0147696. PubMed PMID: 26808049; PubMed Central PMCID: PMC4726741.
- Shuryak I, Brenner DJ. A model of interactions between radiation-induced oxidative stress, protein and DNA damage in Deinococcus radiodurans. J Theor Biol. 2009 Nov 21;261(2):305-17. PubMed PMID: 19679136; PubMed Central PMCID: PMC2774503.
- Quantification of the risks of cancer and other diseases (particularly cardiovascular disease) in patients exposed to ionizing radiation during therapeutic or diagnostic medical procedures
- Ivanidze J, Charalel RA, Shuryak I, Brenner D, Pandya A, Kallas ON, Kesavabhotla K, Segal AZ, Simon MS, Sanelli PC. Effects of Radiation Exposure on the Cost-Effectiveness of CT Angiography and Perfusion Imaging in Aneurysmal Subarachnoid Hemorrhage. AJNR Am J Neuroradiol. 2017 Mar;38(3):462-468. PubMed PMID: 28082263.
- Ng J, Shuryak I. Minimizing second cancer risk following radiotherapy: current perspectives. Cancer Manag Res. 2015;7:1-11. PubMed PMID: 25565886; PubMed Central PMCID: PMC4274043.
- Shuryak I, Lubin JH, Brenner DJ. Potential for adult-based epidemiological studies to characterize overall cancer risks associated with a lifetime of CT scans. Radiat Res. 2014 Jun;181(6):584-91. PubMed PMID: 24828111; PubMed Central PMCID: PMC4157352.
- Brenner DJ, Shuryak I, Einstein AJ. Impact of reduced patient life expectancy on potential cancer risks from radiologic imaging. Radiology. 2011 Oct;261(1):193-8. PubMed PMID: 21771956.
- Mechanistic mathematical modeling of non-targeted ("bystander") effects of ionizing radiation, including their role in radiation carcinogenesis
- Shuryak I, Fornace AJ Jr, Datta K, Suman S, Kumar S, Sachs RK, Brenner DJ. Scaling Human Cancer Risks from Low LET to High LET when Dose-Effect Relationships are Complex. Radiat Res. 2017 Apr;187(4):476-482. PubMed PMID: 28218889.
- Shuryak I. Quantitative modeling of responses to chronic ionizing radiation exposure using targeted and non-targeted effects. PLoS One. 2017;12(4):e0176476. PubMed PMID: 28441437; PubMed Central PMCID: PMC5404850.
- Shuryak I, Brenner DJ, Ullrich RL. Radiation-induced carcinogenesis: mechanistically based differences between gamma-rays and neutrons, and interactions with DMBA. PLoS One. 2011;6(12):e28559. PubMed PMID: 22194850; PubMed Central PMCID: PMC3237439.
- Shuryak I, Sachs RK, Brenner DJ. Biophysical models of radiation bystander effects: 1. Spatial effects in three-dimensional tissues. Radiat Res. 2007 Dec;168(6):741-9. PubMed PMID: 18088188.