Tom K. Hei, PhD

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Overview

Academic Appointments

  • Professor of Radiation Oncology
  • Professor of Environmental Health Sciences

Administrative Titles

  • Vice-Chairman of Radiation Oncology
In risk assessment studies, in vitro neoplastic transformation assays based on rodent fibroblasts are use to obtain quantitative dose response data for environmental carcinogens such as tobacco smoke, radon, asbestos fibers, and heavy metals. Immortalized human bronchial and breast epithelial cell models are used to examine the molecular mechanisms involved in the multistage nature of human carcinogenesis. Activation of oncogenes, loss of tumor suppressor genes, altered signal transduction pathways in radon and asbestos induced bronchial carcinogenesis are currently funded research projects. Emphases are on mechanisms of fiber mutagenesis, effects of reactive oxygen species in fiber toxicity, and the synergistic interaction of asbestos with other environmental carcinogens such as radon and cigarette smoke.

Gender

  • Male

Research

Environmental carcinogenesis, specifically mechanisms of chemical and radiation carcinogenesis mutagenesis at the cellular and molecular level. Fiber toxicology, particularly, the how and why of mineral fibers, including asbestos an other man-made fibers, in causing lung fibrosis and cancers of the lung and peritoneum. Molecular mechanisms of mutagenesis by various environmental carcinogens.

Grants

PHYSICAL AND BIOLOGICAL MODULATORS OF SPACE RADIATION CARCINOGENESIS: MECHANISTICALLY-BASED MODEL D (Federal Gov)

Aug 26 2016 - Aug 25 2020

CYTOPLASMIC DAMAGE AND GENOTOXICITY (Federal Gov)

May 3 2004 - Mar 31 2018

RADIATION BYSTANDER EFFECTS: MECHANISMS (Federal Gov)

Jul 1 2010 - Jun 30 2017

STUDIES ON THE EFFECTS OF COMBINED TREATMENT WITH METFORMIN AND AN DUAL MTOR1/2 INHIBITOR, AZD8055, IN TUMOR CONTROL OF GLIOBLASTOMAS (Private)

Jul 1 2014 - Jun 30 2016

THE ROLE OF THE TGFBI GENE IN HUMAN MESOTHELIOMA PATHOGENESIS AND RESPONSE TO THERAPY (Private)

Jul 1 2013 - Jun 30 2015

RADIATION BYSTANDER EFFECTS: MECHANISMS (Federal Gov)

Feb 1 2000 - Jun 30 2015

MECHANISM OF MESOTHELIOMA PATHOGENESIS: THE ROLE OF THE BETAIGH3 GENE (Private)

Jul 1 2010 - Jun 12 2014

CENTER FOR ENVIRONMENTAL HEALTH IN NORTHERN MANHATTAN (Federal Gov)

Jul 1 1998 - Mar 31 2013

HEALTH EFFECTS AND GEOCHEMISTRY OF ARSENIC AND MANGANESE (Federal Gov)

Jun 1 2000 - Mar 31 2012